Angina Research Today is a free monthly online journal that collates and summarizes the latest research about Angina, including details on symptoms, treatment, causes, prevention, surgery.

Variability in response to aspirin: do we understand the clinical relevance?

Campbell CL, Steinhubl SR

Division of Cardiology, Wilford Hall Medical Center and San Antonio Uniform Health Sciences Consortium, San Antonio, TX, USA. campbell@lackland.af.mil

Aspirin, an irreversible inhibitor of platelet prostaglandin synthase activity, is the cornerstone of therapy for acute coronary syndromes. In recent years, laboratory and clinical data have accumulated that suggest there may be significant individual variability in the response to aspirin and that the effects of aspirin therapy vary significantly over time. There is, as of yet, no cohesive explanation for this variability. The term 'aspirin resistance' has been loosely applied to situations in which the clinical or ex vivo effects of aspirin are less than expected. In this review we discuss the clinical data regarding this phenomenon and the need for prospective evaluation of aspirin non-responders.

Published 21 April 2005 in J Thromb Haemost, 3(4): 665-9.
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